Surgery and emergencies
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Like all anticoagulants, Pradaxa increases risk of bleeding during surgery, so surgical patients may have to temporarily discontinue Pradaxa.1 Read on for information on how to manage your Pradaxa patients who need surgery.

What is the half-life of Pradaxa?

In adults with normal renal function (CrCL ≥80 ml/min) the half-life of Pradaxa is 12–14 hours.1

 


 

What if my Pradaxa patient needs surgery?


  • Generally, Pradaxa should be discontinued at least 24 hours before surgery2
  • In patients at higher risk of bleeding, consider stopping Pradaxa 2–4 days before surgery2

Impaired renal function can increase the half-life of Pradaxa up to ~18 hours. This should be taken into account when considering suspending Pradaxa – see the table for details.

 

Summary of discontinuation rules before surgery1

An image showing information on discontinuing Pradaxa (Dabigatran) before surgery

 

In case of an emergency surgery or urgent procedure, Praxbind can be considered. Praxbind immediately reverses the anticoagulant effect of Pradaxa.

References: 
  1. Pradaxa Summary of Product Characteristics 2016. Boehringer Ingelheim
  2. van Ryn J et al. Thromb Haemost 2010;103:1116–1127.