Surgery and emergencies
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As with all anticoagulants, an overdose with Pradaxa exposes the patient to an increased risk of bleeding. Read on for more information on how to manage a patient in the event of a suspected overdose.


What should I do if I suspect an overdose


In case of a suspected overdose, coagulation tests can help to detect the presence of Pradaxa and determine the bleeding risk. For information see Managing bleeds and Praxbind.

Close clinical surveillance (looking for signs of bleeding or anemia) is recommended throughout the treatment period, especially if risk factors are combined.1

Since Pradaxa is excreted predominantly by the renal route, adequate diuresis must be maintained. In adults with normal renal function (CrCL ≥80 ml/min) the half-life of Pradaxa is 12–14 hours.1

Excessive anticoagulation may require interruption of the anticoagulation effect of Pradaxa. Praxbind is a specific reversal agent that provides immediate reversal of the anticoagulation effect of Pradaxa.2

Consideration should also be given to administration of platelet concentrates in cases where thrombocytopenia is present or long-acting antiplatelet drugs have been used. All symptomatic treatment has to be given according to the physician’s judgment.1

References: 
  1. Pradaxa Summary of Product Characteristics 2016. Boehringer Ingelheim.
  2. Praxbind Summary of Product Characteristics 2016. Boehringer Ingelheim.