Using Pradaxa - Interactions with Pradaxa

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Interactions with Pradaxa

Pradaxa has few significant drug-drug interactions, and is not metabolized by the cytochrome P450 pathway.1

Pradaxa has been shown to interact with P-gp inhibitors:1

  • Co‚Äďadministration with the following strong P-gp inhibitors is contraindicated: systemic ketoconazole, cyclosporine, itraconazole and dronedarone
  • Concomitant treatment with tacrolimus is not recommended
  • Caution should be exercised with mild to moderate P-gp inhibitors (e.g. amiodarone, posaconazole, quinidine, verapamil and ticagrelor).

For a full list of contraindications, please read the Pradaxa Summary of Product Characteristics.

An image to show that Pradaxa (Dabigatran) is not metabolized by the cytochrome P450 pathway
  1. Pradaxa Summary of Product Characteristics 2016. Boehringer Ingelheim.